In 2009 they continued to press forward on the guitar front by releasing the Wolfgang-inspired EVH guitar line. Giornalistica Italia S.p.A.  The divorce was finalized in 2007.  He entered rehabilitation in 2007, and later shared in an interview that he had been sober since 2008. , Van Halen used a variety of pickups including 1970s Mighty Mites, which were made by Seymour Duncan and were copies of DiMarzio Super Distortion pickups.  Two years later, the band changed its name to "Van Halen" and, at the same time, became a staple of the Los Angeles music scene while playing at well-known clubs like the Whisky a Go Go. E questa chitarra se la crea, se la costruisce su misura per le sue necessità. Voglio solo suonare la mia chitarra per far sentire qualcosa alle persone, felicità, tristezza o anche eccitazione". Voglio solo che la mia chitarra suoni per far sentire la gente felice, o triste, o magari eccitarla". The tremolo arm was originally taken from a 1958 Fender Stratocaster, and was later replaced with a Floyd Rose arm.
, Van Halen's 1978 instrumental solo "Eruption", which was voted number 2 in Guitar World's readers poll of the "100 Greatest Guitar Solos", showcased a solo technique called tapping, using both left and right hands on the guitar neck. , Van Halen described supergroup Cream's "I'm So Glad" on the album Goodbye as "mind-blowing".
Negli anni ha scalato tutte le classifiche dell'heavy Metal. “Non riesco a credere che devo scrivere questo, ma mio padre Edward Lodewijk Van Halen ha perso la sua lunga e dura battaglia contro il cancro questa mattina”, ha scritto in un tweet. The guitar had a single Gibson PAF (patent applied for) bridge pickup from a Gibson ES-335, which he enclosed with paraffin wax to prevent feedback. Da tempo lottava con un tumore alla gola, che si è allargato al cervello portandolo alla morte. , In 1981, Van Halen made his first guitar endorsement by launching the 5150 Baretta model with Kramer. While the band had already achieved hard rock superstardom, Eddie became a pop culture icon with the 1983 release of Michael Jackson's "Beat It" ... which featured Eddie's iconic guitar solo. Was pumped for the Motley show that was supposed to be there last summer. , In February 2017, Van Halen donated 75 guitars from his personal collection to Mr. Holland's Opus Foundation, a program that provides musical instruments to students in low-income schools.
 He died from the illness at Saint John's Health Center in Santa Monica, California on October 6, 2020, at the age of 65 surrounded by his wife, Janie; son and Van Halen bassist, Wolfgang; ex-wife Valerie Bertinelli; and brother, Alex; co-founder and drummer of Van Halen.