Latest News on Clinical Trials
CytoDyn Reports Early Results from First Patient in its Phase 1b/2 CCR5+ Metastatic Triple-Negative Breast Cancer Trial
First metastatic triple-negative breast cancer patient showed no detectable circulating tumor cells (CTC) or putative metastatic tumor cells (EMTs) in the peripheral blood. Further, a significant reduction in CCR5 expression was demonstrated on cancer-associated cells...
Rafael Pharmaceuticals Announces Expansion of Phase 2 Trial of CPI-613® (devimistat) for Patients with Relapsed or Refractory Burkitt’s Lymphoma/Leukemia to Massachusetts General Hospital in Boston
Cranbury, N.J., Dec. 02, 2019 (GLOBE NEWSWIRE) -- Rafael Pharmaceuticals, Inc. (“Rafael” or the “Company”), a leader in the growing field of cancer metabolism-based therapeutics, today announced the expansion of its Phase 2 clinical trial of CPI-613® (devimistat) for...
Genkyotex Reports Progress of Setanaxib Phase 2 Investigator Initiated Trials
Phase 2 DKD trial funded by JDRF to expand in Europe and New Zealand 13 patients have completed full 48-week treatment in DKD trial; no safety signals identified Phase 2 IPF trial funded by NIH; poised to initiate patient enrollment following recently received FDA and...
1st Patient Dosed with Cellectis’ Allogeneic UCART22 in Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia
BALLI-01 Clinical Trial Commenced at MD Anderson Cancer Center Regulatory News: Cellectis (ALCLS.PA) (CLLS) (Euronext Growth: ALCLS - Nasdaq: CLLS), a clinical-stage biopharmaceutical company focused on developing immunotherapies based on gene-edited allogeneic CAR...
Clinical Trials and Human Subjects Research
NIH has issued a new definition of what constitutes a clinical trial. The new definition expands research to be included to virtually any behavioral or biological response to a manipulation or intervention and does not have to include a potential clinical...
Philips Announces WE-TRUST Multicenter Clinical Trial to Assess Impact of ‘Direct to Angio Suite’ Workflow on Stroke Patient Outcomes
December 2, 2019 — Amsterdam, the Netherlands – Royal Philips announced a major clinical trial to assess the impact of a ‘Direct to Angio Suite’ workflow on stroke patient outcomes. The study will assess whether with Philips’ advanced image-guided therapy platform it...
SinuSonic Clinical Trial Data Shows Safety and Efficacy for a Novel, Nonpharmacologic Device for Nasal Congestion Relief
COLUMBIA, S.C., Dec. 2, 2019 /PRNewswire/ -- Healthy Humming, LLC is pleased to announce positive topline data from a prospective outcomes study, which assessed the safety and efficacy of the SinuSonic, a nasal congestion treatment device that combines nasal acoustic...
Seattle Genetics and Astellas Announce Clinical Trial Collaboration with Merck to Evaluate Enfortumab Vedotin in Combination with KEYTRUDA® (pembrolizumab) in Patients with Metastatic Urothelial Cancer
- Companies to Initiate Phase 3 Trial to Support Global Registrations - BOTHELL, Wash. & TOKYO--(BUSINESS WIRE)-- Seattle Genetics, Inc. (Nasdaq:SGEN) and Astellas Pharma Inc. (TSE: 4503, President and CEO: Kenji Yasukawa, Ph.D., “Astellas”), today announced a...
Phathom Pharmaceuticals Announces Initiation of Pivotal Phase 3 Clinical Trial for Vonoprazan in Erosive Esophagitis
BUFFALO GROVE, Ill.--(BUSINESS WIRE)--Phathom Pharmaceuticals, Inc. (Nasdaq: PHAT), a late clinical-stage biopharmaceutical company focused on developing and commercializing novel treatments for gastrointestinal diseases, announced today the initiation of PHALCON-EE,...
Oragenics, Inc. Announces Completion of Enrollment of Its Phase 2 Clinical Trial for AG013 in Oral Mucositis
TAMPA, Fla.--(BUSINESS WIRE)--Oragenics, Inc. (NYSE American: OGEN), a leader in the development of new antibiotics against infectious diseases and effective treatments for oral mucositis (OM), today announced the completion of enrollment in its ongoing double-blind,...
Concert Pharmaceuticals Initiates CTP-692 Phase 2 Trial in Schizophrenia
LEXINGTON, Mass.--(BUSINESS WIRE)--Dec 2, 2019-- Concert Pharmaceuticals, Inc. (NASDAQ: CNCE) today announced the initiation of a Phase 2 clinical trial evaluating CTP-692 as an adjunctive treatment for schizophrenia. CTP-692 is a deuterated form of D-serine, an...
Grifols to present latest Alzheimer’s clinical trial results
BARCELONA, Spain, Dec. 2, 2019 /PRNewswire/ -- Grifols (MCE: GRF, MCE: GRF.P, NASDAQ: GRFS), a leading global producer of plasma-derived medicines, will present the final and complete clinical, biomarker and neuroimaging results of its AMBAR (Alzheimer Management by...
TrialScope Launches Clinical Trials Website for EMD Serono
JERSEY CITY, N.J., Dec. 2, 2019 /PRNewswire-PRWeb/ -- TrialScope, the global leader in clinical trial transparency and disclosure compliance solutions, has worked with EMD Serono, the North American branch of the healthcare business of Merck KGaA, Darmstadt, Germany,...
Innovent Announces First Patient Dosed in Phase I Clinical Trial of Anti-PD-1/HER2 Bispecific Antibody in China
SUZHOU, China, Nov. 26, 2019 /PRNewswire/ -- Innovent Biologics, Inc. ("Innovent" or "the Company") (HKEX: 01801), a world-class biopharmaceutical company that develops and commercializes high quality medicines for the treatment of oncology, autoimmune, metabolic and...
OTITOPIC™ New Clinical Trial Results Continue to Demonstrate Inhibition of Platelet Aggregation in Two Minutes With Dry Powder Inhalation of Aspirin Formulation for High Risk Patients to Treat Suspected Acute Myocardial Infarction (MI)
LOS ANGELES--(BUSINESS WIRE)--OTITOPIC – A clinical-stage dry powder inhalation of aspirin pharmaceutical company pioneering the development of antithrombotic treatments for use at the time of suspected acute myocardial infarction (MI), today announced the successful...
Study protocol of a phase II clinical trial of oral metformin for the intravesical treatment of non-muscle invasive bladder cancer.
Non-muscle-invasive bladder cancer (NMIBC) is the most common neoplasm of the urinary tract and requires life-long invasive surveillance to detect disease recurrence. Currently, there are no effective oral therapies that delay disease recurrence or progression. We...
Clinerion partners with Eugen to expand Patient Network Explorer coverage to patients and hospitals in Uruguay
Eugen will support the expansion of Clinerion’s Patient Network Explorer to hospitals and clinical trial sites in Uruguay. Eugen will also offer Patient Network Explorer services on behalf of Clinerion to clinical researchers and trial sponsors in Uruguay. MONTEVIDEO,...
Immunovant Initiates Dosing in ASCEND-GO 2, a Phase 2b Trial of IMVT-1401 in Patients with Graves’ Ophthalmopathy (GO)
IMVT-1401, a fully human anti-FcRn antibody designed to be administered via subcutaneous injection, is the only anti-FcRn antibody known to be in clinical development for the treatment of GO Topline results from the ASCEND-GO 2 program are expected in early 2021...
PharmAbcine’s Olinvacimb, able to manage the first recruitment of patients for phase II clinical trial
Safety and efficacy evaluation will be performed on 36 patients from 3 hospitals located in US and Australia While bevacizumabparticularly blocks the signaling activated by VEGF-A, Olinvacimab manages to block the signaling activated by VEGF-A, C, and D. PharmAbcine,...
Akcea and Ionis Announce Initiation of NEURO-TTRansform Phase 3 Clinical Trial for AKCEA-TTR-LRx in Patients with Polyneuropathy Driven by Hereditary TTR Amyloidosis
BOSTON and CARLSBAD, Calif., Nov. 25, 2019 -- Akcea Therapeutics Inc. (NASDAQ: AKCA), a majority-owned affiliate of Ionis Pharmaceuticals, Inc., and Ionis Pharmaceuticals, Inc. (NASDAQ: IONS), today announced initiation of the NEURO-TTRansform Phase 3 clinical trial...
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