Latest News on Clinical Trials
HER2-targeted CAR T-cell therapy shows promising antitumor activity in patients with sarcoma
ATLANTA -- A combination of chemotherapy and chimeric antigen receptor (CAR) T cells designed to target the protein HER2 was found to be safe and showed clinical responses in pediatric and adult patients with advanced HER2-positive sarcoma, according to results from a...
New glioblastoma vaccine shows promising results in phase Ib clinical trial
A brain-cancer vaccine more than 20 years in the making suspends cancer growth in patients enrolled in early-stage trial. Glioblastoma is the most aggressive type of primary brain cancer, one with a prognosis of 11-15 months with standard treatment. Results from a...
Selecta Biosciences Initiates Head-to-Head Clinical Trial (COMPARE) of SEL-212 vs. KRYSTEXXA® in Patients with Chronic Refractory Gout and Strengthens Management Team
-First patient enrolled in COMPARE trial evaluating efficacy and safety of SEL-212 v. KRYSTEXXA® in patients with chronic refractory gout -Strengthened management and clinical teams with the appointments of Elona Kogan, J.D. as General Counsel & Corporate...
Updated Phase 1 Clinical Trial Monotherapy Data for IDE196 in Metastatic Uveal Melanoma to be Presented at AACR Conference
IDEAYA Biosciences, Inc., an oncology-focused precision medicine company committed to the discovery and development of targeted therapeutics to treat cancer, announced that Novartis will present a poster with data from an ongoing clinical trial evaluating the...
Clinical trial finds therapy to be well-tolerated in patients with aggressive brain tumour
A phase I clinical trial that set out to assess the safety of a new combination therapy for a type of aggressive brain tumour has found the treatment to be well tolerated in patients. A phase I clinical trial that set out to assess the safety of a new combination...
Data Safety Monitoring Board Recommends Continuation Of Phase III Clinical Studies Of BACE Inhibitor Elenbecestat In Early Alzheimer’s Disease
Eisai Co., Ltd. (Headquarters: Tokyo, CEO: Haruo Naito, "Eisai") announced today that in the 8th meeting of the Data Safety Monitoring Board (DSMB) for the global Phase III clinical studies (MISSION AD) on the investigational oral BACE (beta amyloid cleaving enzyme)...
Mareana Included in Gartner Research: Cited Among “Clinical Vendors Building Value with AI Technology”
Mareana today announced that it has been included in Gartner's January 17, 2019 artificial intelligence (AI) research note, Life Sciences CIOs, Accelerate Clinical Development with New Applications of Artificial Intelligence, written by analysts Jeff Smith and Michael...
Proteon Therapeutics’ Kidney Disease Drug Flunks Phase III Trial
Proteon Therapeutics, based in Waltham, Mass., announced that its PATENCY-2 Phase III clinical trial of vonapanitase in chronic kidney disease (CKD) failed to meet its co-primary endpoints. Vonapanitase was being evaluated in patients with CKD undergoing creation of a...
Updated Phase 1 Clinical Trial Monotherapy Data for IDE196 in Metastatic Uveal Melanoma to be Presented at AACR Conference
IDEAYA Biosciences, Inc., an oncology-focused precision medicine company committed to the discovery and development of targeted therapeutics to treat cancer, announced that Novartis will present a poster with data from an ongoing clinical trial evaluating the...
Selecta Biosciences Initiates Head-to-Head Clinical Trial (COMPARE) of SEL-212 vs. KRYSTEXXA® in Patients with Chronic Refractory Gout and Strengthens Management Team
-First patient enrolled in COMPARE trial evaluating efficacy and safety of SEL-212 v. KRYSTEXXA® in patients with chronic refractory gout -Strengthened management and clinical teams with the appointments of Elona Kogan, J.D. as General Counsel & Corporate...
Eisai: Data Safety Monitoring Board Recommends Continuation of Phase III Clinical Studies of Bace Inhibitor Elenbecestat in Early Alzheimer’s Disease
Eisai Co., Ltd. announced today that in the 8th meeting of the Data Safety Monitoring Board (DSMB) for the global Phase III clinical studies (MISSION AD) on the investigational oral BACE (beta amyloid cleaving enzyme) inhibitor elenbecestat (development code: E2609)...
Phio and Glycostem to Collaborate on Use of its sd-rxRNA® platform and Glycostem’s oNKord® Cell Therapy Products for the Next Generation of Natural Killer Cell-based Immunotherapy for Cancer Treatment
Phio Pharmaceuticals Corp. (NASDAQ: PHIO) announced today that it has entered into a research collaboration with Glycostem Therapeutics BV to explore the potential synergies of using Phio's self-delivering RNAi technology (sd-rxRNA®) in combination with Glycostem's...
Supernus Announces P304 Phase III Data Confirming Positive Results from Previous Three Phase III Studies on SPN-812 in ADHD
400 mg dose reached statistical significance compared to placebo, consistent with previous Phase III studies: • Change versus baseline in ADHD Rating Scale 5, p-value = 0.0082 • Effect size of 0.66 • CGI-I secondary endpoint, p-value = 0.0051...
Tocagen to Present Updated Data from Clinical and Preclinical Studies at Two Scientific Conferences
Tocagen Inc. (Nasdaq: TOCA), a clinical-stage, cancer-selective gene therapy company, today announced three presentations of updated clinical and preclinical data at the American Association for Cancer Research (AACR) Annual Meeting 2019, to be held March 29-April...
Silence Therapeutics Submits Clinical Trial Application for SLN124
Phase Ib First-in-Human study in ß -Thalassemia and MDS patients, with the first patient expected to enter the clinic in Q3 2019 Silence Therapeutics, PLC (LON: SLN) (“Silence” or “the Company”) a leader in the discovery, development and delivery of novel RNA...
BiondVax to Provide Update of M-001 Universal Flu Vaccine Pivotal Phase 3 Clinical Trial at IVW2019 Conference
BiondVax Pharmaceuticals Ltd. (NASDAQ: BVXV), developer of the M-001 universal influenza vaccine candidate, reported today it will present next week at the Influenza Vaccines for the Worldconference in Edinburgh, Scotland, UK. Joshua Phillipson, BiondVax's Head of...
Tricida Announces Positive Results From Long-Term Clinical Trial of TRC101 in Patients With CKD and Metabolic Acidosis
Blinded, randomized, placebo-controlled, 40-week extension trial, TRCA-301E, met its primary and all secondary endpoints, supporting the long-term safety and efficacy profile of TRC101 Patients treated with TRC101 showed a significant reduction in all-cause mortality...
Hansa Biopharma Receives Ethics and Regulatory Clearance to Start Phase 2 Study of Imlifidase in Acute Antibody Mediated Rejection in Kidney Transplantation
LUND, Sweden, March 26, 2019 /PRNewswire/ -- Hansa Biopharma AB(NASDAQ Stockholm: HNSA), the leader in immunomodulatory enzyme technology for rare IgG-mediated diseases, announced today that it received Clinical Trial Application and Ethics Committee approvals for the...
Can medicinal cannabis treat the tics in Tourette syndrome?
Lambert Initiative facilitating supply for clinical trial A pioneering clinical trial investigating medicinal cannabis as a potential treatment for people living with Tourette syndrome will be conducted by Wesley Medical Research, with the cannabis supply facilitated...
ISCR welcomes new drugs and clinical trial rules, 2019
New rules well balanced, focused on patient rights, safety and well-being Welcoming the New Drugs and Clinical Trial Rules, 2019 which were notified by the Ministry of Health & Family Welfare and made public on March 25th, the Indian Society for Clinical Research...
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