Lexaria Bioscience Corp. (OTCQX: LXRP) (CSE: LXX) (the ″Company″ or ″Lexaria″), a drug delivery platform innovator, is pleased to announce additional significant findings upon completion of further data analyses from its 2018 randomized, placebo-controlled, double-blinded European human clinical study that evaluated TurboCBD™, the Company’s proprietary, DehydraTECH™ powered, cannabidiol (″CBD″) fortified hemp-oil capsule.

A single 90mg dose of TurboCBD provided evidence of lower blood pressure; higher blood flow to the brain; faster delivery onset of CBD into the bloodstream; and, larger quantities of CBD within the blood compared to a single 90mg dose of generic CBD.

Key metabolic and hemodynamic performance findings linked to bioavailability enhancements were revealed in the study, which compared a 90 mg dose of Lexaria’s TurboCBD™ to a 90 mg dose without Lexaria’s DehydraTECH™ technology (the ″positive control″) as well as a placebo, as follows:

On August 1, 2018, the Company reported data from this study that demonstrated much faster absorption of CBD in the subjects within the first 30 minutes of the study as well as higher bioavailability throughout the course of the study. The additional results announced today provide additional support for the pronounced effectiveness of Lexaria’s DehydraTECH™ technology at enabling superior cannabinoid delivery upon ingestion. The significant MAP results suggest potential utility of Lexaria’s technology for CBD-induced reduction of blood pressure, while the enhanced MCA conductance also supports previous pre-clinical findings demonstrating the ability of Lexaria’s technology to enhance drug delivery to the brain tissues as a principal site of action for compounds like cannabinoids.

″The findings that Lexaria’s DehydraTECH™ technology can enable superior cannabinoid delivery are unique in this healthy-human clinical trial. However, the findings that the technology can proffer a positive influence on blood pressure and perfusion to the brain are truly remarkable,″ said Professor Philip Ainslie, Ph.D., Principal Investigator and Co-Director of the Centre for Heart, Lung and Vascular Health, UBC Okanagan Campus, Kelowna, Canada. ″The potential benefits of this approach, but over the acute and more chronic time periods, in more middle-aged or elderly populations should now be prioritized. Establishing the impact of CBD delivery on the health of the circulatory systems, including the brain, could have major implications for the adjunct treatment of high blood pressure and some neurological diseases.″

The study also provided exploratory findings with respect to relative levels of several CBD liver metabolites that were analysed for all subjects. Levels of 6α-OH-CBD, 7-OH-CBD, and 7-CBD-COOH were distinctly lower, albeit not statistically, initially in all cases and throughout the course of the study in two cases. These findings are aligned with Lexaria’s theorized DehydraTECH™ mechanism of action whereby it is believed to stimulate lymphatic drug uptake and routing to the systemic circulation bypassing liver metabolism to some degree as the basis for its rapid and pronounced effectiveness.

Based on the positive outcomes of this study, Lexaria intends to conduct further human clinical investigations within the next year using DehydraTECH™ for cannabinoids with expanded numbers of subjects over a wider age range and selected pathologies. Additional data and reports will be provided from future studies as they become available.

About Lexaria

Lexaria Bioscience Corp. has developed and out-licenses its disruptive delivery technology that promotes healthier ingestion methods, lower overall dosing and higher effectiveness of lipophilic active molecules. Lexaria has multiple patents pending in over 40 countries around the world and has patents granted in the USA and in Australia for utilization of its DehydraTECHTM delivery technology. Lexaria’s technology provides increases in intestinal absorption rates; more rapid delivery to the bloodstream; and important taste-masking benefits, for orally administered bioactive molecules including cannabinoids, vitamins, non-steroidal anti-inflammatory drugs (NSAIDs),nicotine and other molecules.

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Lexaria Bioscience Corp.

Alex Blanchard, Communications Manager

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