CD8+ T Cell agent could be used for early prediction of therapeutic response in metastatic cancer patients

ImaginAb Inc. announced the enrollment of the first patient in the Phase II clinical trial of the company’s CD8+ T Cell imaging agent. The trial will enroll metastatic cancer patients and will study the correlation of imaging signals observed using ImaginAb’s CD8+ T cell ImmunoPET imaging agent, standard-of-care scans and immunohistochemistry analysis of CD8 in biopsied tissues. The trial will also measure changes in CD8+ T-cell distribution before and after immuno-oncology therapies. The study is, in part, financially supported by Boehringer Ingelheim and contributes to the aims of the strategic collaboration between ImaginAb and Boehringer Ingelheim to develop ImaginAb’s CD8+ T cell Immuno-PET imaging agent, IAB22M2C.

IAB22M2C is designed to be used with positron emission tomography (PET) scan technology to non-invasively measure CD8+ T cell tumor infiltrates in patients with cancer, including the identification of changes in CD8+ T cell tumor infiltrates induced by immuno-oncology treatments. This investigational approach has the potential to guide the development of immunomodulatory agents and combinations by assessing whether a patient’s immune system responds to such agents, thereby offering an early prediction of therapeutic response.

The Phase II trial follows on the heels of a recently completed Phase I study which, according to ImaginAb, showed an excellent safety profile and encouraging preliminary efficacy of the radiotracer.

For more information: www.imaginab.com

SEARCH FOR STUDIES